Recent advances in glucose-oxidase-based nanocomposites for diabetes diagnosis and treatment
Dejun Yang, Chunyan Cai, Kai Liu, Zhaolei Peng, Chunmei Yan, Jingjing Xi, Fan Xie, Xiaofang Li
Abstract
, metal-organic backbones, and mesoporous silica nanoparticles) have been developed for the control of blood glucose concentrations based on GOx catalytic chemistry. These nano-delivery carriers are capable of releasing insulin in response to GOx-mediated changes in the microenvironment, allowing for a rapid return of the blood microenvironment to a normal state. Therefore, glucose biosensors and insulin delivery vehicles immobilized with GOx are important tools for the diagnosis and treatment of diabetes. This paper reviews the characteristics of various GOx-based nanomaterials developed for glucose biosensing and insulin-responsive release as well as research progress, and also highlights the current challenges and opportunities facing this field.