Hypolipidemic effects of protein hydrolysates from <i>Trachinotus ovatus</i> and identification of peptides implied in bile acid-binding activity using LC-ESI-Q-TOF-MS/MS
Peng Wan, Deke Chen, Hua Chen, Xiaolian Zhu, Xin Chen, Huili Sun, Jianyu Pan, Bingna Cai
Abstract
experiments indicated that the TOPHs could effectively reduce total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and the atherogenic index (AI), while they could evidently increase the high-density lipoprotein cholesterol (HDL-C) content. Furthermore, TOPHs exerted a marked protective effect on hepatorenal function, as evidenced by decreased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine (CREA). Histopathological studies confirmed that TOPHs evidently protected the liver from histological alterations. In summary, for the first time, hypolipidemic effects and subsequential identification were obtained from TOPHs, which are promising natural ingredients that could potentially be employed in the management of hyperlipidemia.