Atorvastatin suppresses the progression of cervical cancer via regulation of autophagy.
Bo Sheng, Yizuo Song, Jianan Zhang, Ruyi Li, Zhiwei Wang, Xueqiong Zhu
Abstract
. In addition, co-culture with GGPP almost completely reversed the morphological change and apoptosis induced by ATO in cervical cancer cells. Furthermore, ATO induced cellular autophagy in cervical cancer cells, which was confirmed by an increase of LC3-I into LC3-II conversion, downregulation of p62 expression, regulation of AMPK and Akt/mTOR pathways. Moreover, pharmacologic inhibition of autophagy using either Baf-A1 or 3-MA significantly enhanced ATO-mediated apoptosis on cervical cancer cells. In conclusion, combination of ATO with autophagy inhibitors could emerge as a new therapeutic strategy for cervical cancer treatment.
Topics & Concepts
AutophagyApoptosisDownregulation and upregulationPI3K/AKT/mTOR pathwayCancer researchAtorvastatinAMPKCervical cancerCancerMedicineCancer cellIn vivoProtein kinase BCell growthPharmacologyChemistryInternal medicineBiologyCell biologyKinaseBiochemistryGeneProtein kinase ABiotechnologyCancer, Lipids, and MetabolismAutophagy in Disease and TherapyRNA modifications and cancer