Colistin Heteroresistance Is Largely Undetected among Carbapenem-Resistant <i>Enterobacterales</i> in the United States
Victor I. Band, Sarah W. Satola, Richard D. Smith, David A. Hufnagel, Chris Bower, Andrew B. Conley, Lavanya Rishishwar, Suzanne E. Dale, Dwight J. Hardy, Roberto L. Vargas, Ghinwa Dumyati, Marion Kainer, Erin C. Phipps, Rebecca Pierce, Lucy Wilson, Matthew D. Sorensen, Erik Nilsson, I. King Jordan, Eileen M. Burd, Monica M. Farley, Jesse T. Jacob, Robert K. Ernst, David S. Weiss
Abstract
strains may inform colistin treatment recommendations. Overall, the rate of colistin nonsusceptibility was more than double the level detected by clinical diagnostics, suggesting that the prevalence of colistin nonsusceptibility among CRE may be higher than currently appreciated in the United States.
Topics & Concepts
ColistinCarbapenemMicrobiologyMedicineVirologyBiologyAntibioticsAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility TestingEnterobacteriaceae and Cronobacter Research