Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice
Sherif E. Emam, Nehal E. Elsadek, Amr S. Abu Lila, Haruka Takata, Yoshino Kawaguchi, Taro Shimizu, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Topics & Concepts
MicrovesiclesPEGylationExosomePEG ratioChemistryIn vivoLiposomePharmacologyExtracellular vesicleMedicineBiologyBiochemistrymicroRNAPolyethylene glycolEconomicsFinanceGeneBiotechnologyExtracellular vesicles in diseaseRNA Interference and Gene DeliveryImmunotherapy and Immune Responses