IS <i>26</i> Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics
Dawei Wei, Nai-Kei Wong, Yuqin Song, Gang Zhang, Chao Wang, Juan Li, Jie Feng
Abstract
Klebsiella pneumoniae carbapenemases (KPCs) are powerful β -lactamases that enable Gram-negative pathogens to destroy clinically important carbapenems in antibiotic therapies. In particular, KPC-2 is difficult to detect due to a lack of instrument sensitivity in regular laboratory screens, which leads to misdiagnosis and poor treatment outcomes.
Topics & Concepts
Klebsiella pneumoniaeAntibioticsCarbapenemMicrobiologyIntensive care medicineMedicineBiologyComputational biologyGeneticsGeneEscherichia coliAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsAntibiotics Pharmacokinetics and Efficacy