Pharmacological targeting of differential DNA repair, radio-sensitizes WRN-deficient cancer cells in vitro and in vivo
Pooja Gupta, Bhaskar Saha, Subrata Chattopadhyay, Birija Sankar Patro
Topics & Concepts
RAD51Cancer researchDNA repairGene silencingHomologous recombinationBiologyMAPK/ERK pathwayp38 mitogen-activated protein kinasesDNA damageCell biologyMolecular biologyKinaseGeneticsDNAGeneDNA Repair MechanismsCarcinogens and Genotoxicity AssessmentPARP inhibition in cancer therapy