Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer
Junbao Zhang, Ying Ying, Meiqi Li, Maolin Wang, Xiaoyan Huang, Min Jia, Junhui Zeng, Canjie Ma, Yixiang Zhang, Chen Li, Xiaomei Wang, Xing‐sheng Shu
Abstract
: Our study provides a novel rational strategy to eradicate TICs through reshaping epigenetic landscape in CRC, which might also be beneficial for optimizing current therapeutics.
Topics & Concepts
ReprogrammingColorectal cancerCancer researchHistoneEnhancerBiologyCancerChemistryMedicineGeneticsTranscription factorGeneEpigenetics and DNA MethylationHistone Deacetylase Inhibitors ResearchCancer-related gene regulation