SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines
Giovanni Salvatori, Laura Luberto, Mariano Maffei, Luigi Aurisicchio, Giuseppe Roscilli, Fabio Palombo, Emanuele Marra
Abstract
COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Spike ProteinPandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakSpike (software development)VirologyMedicineFocus (optics)Computer scienceInfectious disease (medical specialty)DiseaseOutbreakPhysicsPathologyOpticsSoftware engineeringSARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesCOVID-19 Clinical Research Studies