Epigenetic Landscape of HIV-1 Infection in Primary Human Macrophage
Fang Lü, Urvi Zankharia, Olga Vladimirova, Yanjie Yi, Ronald G. Collman, Paul M. Lieberman
Abstract
Macrophages serve as a reservoir for long-term persistence and chronic production of HIV. We found an atypical epigenetic control of HIV in macrophages marked by heterochromatic H3K9me3 despite active viral transcription. HIV infection induced changes in macrophage nuclear morphology and epigenetic regulatory factors. These findings may identify new mechanisms to control chronic HIV expression in infected macrophages.
Topics & Concepts
BiologyEpigeneticsHeterochromatinVirologyDNA methylationH3K4me3Jurkat cellsSAMHD1ImmunologyGeneticsChromatinReverse transcriptaseT cellImmune systemGene expressionPromoterDNAGeneRNAHIV Research and TreatmentEpigenetics and DNA MethylationHIV/AIDS Research and Interventions