Role of Matrix Metalloproteinases in Myelin Abnormalities and Mechanical Allodynia in Rodents with Diabetic Neuropathy
Xueting Deng, Pingchuan Ma, Mingzheng Wu, Huabao Liao, Xue‐Jun Song
Abstract
mice. Finally, systematic administration of α-lipoic acid significantly suppressed STZ-induced mechanical allodynia by inhibiting MMP-9 and rescuing MMP-2 activity. These findings support a new mechanism underlying the pathogenesis of diabetic neuropathy and suggest a potential target for DNP treatment. Gelatinases MMP-9 and MMP-2 play a critical role in the pathogenesis of diabetic neuropathy and may serve as a potential treatment target. MMP-9/2 underlies the mechanism of α-lipoic acid in diabetic neuropathy, providing a potential target for the development of novel analgesic and anti-inflammatory drugs.
Topics & Concepts
Matrix metalloproteinaseMedicineDiabetic neuropathyAllodyniaDiabetes mellitusMyelinPharmacologyInternal medicineEndocrinologyHyperalgesiaCentral nervous systemNociceptionReceptorPain Mechanisms and TreatmentsBotulinum Toxin and Related Neurological DisordersNerve injury and regeneration