High-Fidelity Sequence-Selective Duplex Formation by Recognition-Encoded Melamine Oligomers
Pavle Trošelj, Peter Bolgar, Pablo Ballester, Christopher A. Hunter
Abstract
3-mer show that 1,3-folding does not take place either. ITC was used to characterize interactions between all pairwise combinations of the six different 3-mer sequences, and the sequence complementary duplexes are approximately an order of magnitude more stable than duplexes with a single base mismatch. High-fidelity duplex formation combined with the synthetic accessibility of the monomer building blocks makes these systems attractive targets for further investigation.
Topics & Concepts
ChemistryIntramolecular forceIsothermal titration calorimetryNuclear magnetic resonance spectroscopyMonomerOligomerDuplex (building)Folding (DSP implementation)CrystallographyMelamineBase pairStereochemistryPolymerPolymer chemistryDNAOrganic chemistryPhysical chemistryEngineeringElectrical engineeringBiochemistrySynthesis and Characterization of Heterocyclic CompoundsDNA and Nucleic Acid ChemistryLuminescence and Fluorescent Materials