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Switching from 2-pyridination to difluoromethylation: ligand-enabled nickel-catalyzed reductive difluoromethylation of aryl iodides with difluoromethyl 2-pyridyl sulfone

Wei Du, Qinyu Luo, Zhiqiang Wei, Xiu Wang, Chuanfa Ni, Jinbo Hu

2023Science China Chemistry23 citationsDOI

Topics & Concepts

ReagentArylChemistrySulfoneCombinatorial chemistryReductive eliminationNickelCatalysisLigand (biochemistry)ElectrophilePhosphineBond cleavageMedicinal chemistryOrganic chemistryBiochemistryAlkylReceptorFluorine in Organic Chemistry
Switching from 2-pyridination to difluoromethylation: ligand-enabled nickel-catalyzed reductive difluoromethylation of aryl iodides with difluoromethyl 2-pyridyl sulfone | Litcius