Site-selective coupling of remote C(sp<sup>3</sup>)–H/<i>meta</i>-C(sp<sup>2</sup>)–H bonds enabled by Ru/photoredox dual catalysis and mechanistic studies
Hongchao Liu, Xiangtao Kong, Xiao-Ping Gong, Yuke Li, Zhi‐Jie Niu, Xue‐Ya Gou, Xuesong Li, Yu‐Zhao Wang, Wei‐Yu Shi, Yan‐Chong Huang, Xue‐Yuan Liu, Yong‐Min Liang
Abstract
A novel photoinduced Ru/photocatalyst-cocatalyzed regioselective cross-dehydrogenative coupling of dual remote C–H bonds, including inert γ-C(sp 3 )–H bonds in amides and meta -C(sp 2 )–H bonds in arenes, to construct meta -alkylated arenes has been accomplished.
Topics & Concepts
RegioselectivityChemistryCatalysisCoupling reactionSubstrate (aquarium)Reactivity (psychology)PhotochemistryCombinatorial chemistrySelectivityDensity functional theoryStereochemistryComputational chemistryOrganic chemistryGeologyMedicineAlternative medicinePathologyOceanographyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions