Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency
Hannah M. Kyllo, Dong Wang, Ramón A. Lorca, Colleen G. Julian, Lorna G. Moore, Randall B. Wilkening, Paul J. Rozance, Laura D. Brown, Stephanie R. Wesolowski
Abstract
These results suggest increased placental utilization of pyruvate from the fetus, without higher maternal glucose uptake, and lower amino acid shuttling in the placental insufficiency-induced intrauterine growth restriction (PI-IUGR) placenta. AMPK activation was associated with oxidative stress and PDH activity, supporting a putative link between oxidative stress, AMPK, and pyruvate utilization. These differences in fetoplacental nutrient sensing and shuttling may represent adaptive strategies enabling the placenta to maintain oxidative metabolism at the expense of fetal growth.
Topics & Concepts
Internal medicineEndocrinologyGlutaminePlacental insufficiencyFetusBiologyPlacentaIntrauterine growth restrictionMetabolismBiochemistryAmino acidMedicinePregnancyGeneticsPregnancy and preeclampsia studiesBirth, Development, and HealthGestational Diabetes Research and Management