Membrane-camouflaged supramolecular nanoparticles for co-delivery of chemotherapeutic and molecular-targeted drugs with siRNA against patient-derived pancreatic carcinoma
Honglin Tang, Yanan Xue, Bowen Li, Xiaojie Xu, Fu Zhang, Jiajing Guo, Qijun Li, Tingting Yuan, Yuan Chen, Yubin Pan, Ping Yuan, Da Li
Abstract
. Excitingly, the systemic injection of such a biomimetic drug co-delivery system not only resulted in superior inhibitory effects against orthotopic pancreatic tumor and patient-derived tumor (PDX), but also greatly extended the survival rate of tumor-bearing mice. Our findings provide a promising therapeutic strategy against pancreatic cancer through the enhanced synergistic effect of target therapy, chemotherapy and anti-fibrotic therapy, which represents an appealing way for pancreatic cancer treatment.
Topics & Concepts
Pancreatic cancerGemcitabineCancer researchDrug deliveryTumor microenvironmentErlotinibMedicineCancerPharmacologyChemistryInternal medicineEpidermal growth factor receptorTumor cellsOrganic chemistryNanoplatforms for cancer theranosticsPancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis