LncRNA 2310043L19Rik inhibits differentiation and promotes proliferation of myoblast by sponging miR-125a-5p
Rongyang Li, Bojiang Li, Ming Shen, Yan Cao, Xuan Zhang, Weijian Li, Jingli Tao, Wangjun Wu, Honglin Liu
Abstract
. RNA molecules of lnc-231 acted mechanistically as competing endogenous RNAs (ceRNA) to target miR-125a-5p, whereas miR-125a-5p binds to the 3'-UTR of E2F3 mRNA to inhibit its function. Collectively, lncRNA 2310043L19Rik promotes proliferation and inhibits differentiation of myoblast cells by attenuating the function of miR-125a-5p.
Topics & Concepts
Competing endogenous RNAmicroRNACell biologyLong non-coding RNABiologyMyocyteMessenger RNAFunction (biology)In vitroSkeletal muscleRNAGeneBiochemistryEndocrinologyCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA Research and Splicing