Hydroxyl Radical Overproduction in the Envelope: an Achilles’ Heel in Peptidoglycan Synthesis
Sean Giacomucci, Laura Álvarez, Christopher D. A. Rodrigues, Felipe Cava, Catherine Paradis‐Bleau
Abstract
Oxidative stress is caused by the production and excessive accumulation of oxygen reactive species. In bacterial cells, oxidative stress mediated by hydroxyl radicals is typically associated with DNA damage in the cytoplasm.
Topics & Concepts
Cell envelopePeptidoglycanCell biologyOxidative stressBiologyMutantBiochemistryOverproductionOxidative phosphorylationDNA damageBacterial cell structureReactive oxygen speciesInner membraneChemistryEscherichia coliCell wallMitochondrionDNABacteriaGeneGeneticsVibrio bacteria research studiesAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensing