Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells
Guyu Qin, Eun‐Sil Park, Xueqing Chen, Sen Han, Dongxi Xiang, Fang Ren, Gang Liu, Huidong Chen, Guo‐Cheng Yuan, Zhe Li
Abstract
OSE cells express similar genes largely by themselves, raising a possibility that they serve as their own niche. The differences in intrinsic expression programs and niche organizations of FTE and OSE cells may contribute to their different courses toward the development of EOCs.
Topics & Concepts
LGR5NicheBiologyStem cellCell biologyFallopian tubeStromal cellProgenitor cellEpitheliumCancer stem cellCancer researchGeneticsAnatomyEcologyOvarian cancer diagnosis and treatmentSingle-cell and spatial transcriptomicsCancer Cells and Metastasis