Cefiderocol Antimicrobial Susceptibility Testing against Multidrug-Resistant Gram-Negative Bacilli: a Comparison of Disk Diffusion to Broth Microdilution
C. Paul Morris, Yehudit Bergman, Tsigedera Tekle, John A. Fissel, Pranita D. Tamma, Patricia J. Simner
Abstract
Antimicrobial susceptibility testing (AST) of cefiderocol poses challenges because of its unique mechanism of action (i.e., requiring an iron-depleted state) and due to differences in interpretative criteria established by the Clinical and Laboratory Standards Institute (CLSI), U.S. Food and Drug Administration (FDA), and European Committee on Antimicrobial Susceptibility Testing (EUCAST). Our objective was to compare cefiderocol disk diffusion methods (DD) to broth microdilution (BMD) for AST of Gram-negative bacilli (GNB).
Topics & Concepts
Broth microdilutionBacilliMicrobiologyGramAntimicrobialBiologyMultiple drug resistanceBacteriaMinimum inhibitory concentrationDrug resistanceGeneticsAntibiotic Resistance in BacteriaClostridium difficile and Clostridium perfringens researchAntibiotics Pharmacokinetics and Efficacy