Long-term maternal intake of inulin exacerbated the intestinal damage and inflammation of offspring rats in a DSS-induced colitis model
Ying He, Xie Peng, Yang Liu, Qing Wu, Qiang Zhou, Yingyan Huang, Shiya Liu, Liang Hu, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Jian Li, Xuemei Jiang, Yong Zhuo, De Wu, Lianqiang Che
Abstract
, which were the highest enriched in INU + DSS rats. The level of acetate in the colonic digesta of INU + DSS rats was lower than that in FFD and INU rats. These results indicated that long-term maternal intake of inulin exacerbated the intestinal damage and inflammation of DSS-induced offspring rats, associated with the decreased level of acetate and altered intestinal microbiota.
Topics & Concepts
InulinOffspringMyeloperoxidaseInflammationDiamine oxidaseCecumEndocrinologyHistopathologyInternal medicineMedicinePhysiologyAndrologyChemistryPregnancyBiologyFood sciencePathologyBiochemistryGeneticsEnzymeGut microbiota and healthChild Nutrition and Feeding IssuesInfant Nutrition and Health