Diet composition drives tissue-specific intensity of murine enteric infections
Helene Israelson, Amalie Vedsted-Jakobsen, Ling Zhu, Aurélie Gagnaire, Alexandra von Münchow, Nina Polakovicova, Angela H. Valente, Ali Raza, Audrey Inge Schytz Andersen‐Civil, John Elmerdahl Olsen, Laura J. Myhill, Peter Geldhof, Andrew R. Williams
Abstract
) infection burdens were equivalent in mice fed with chow, inulin-enriched SSD, or SSD, despite higher cyst excretion in chow-fed mice. Collectively, our results point to a tissue- and pathogen-restricted effect of dietary fiber levels on enteric infection intensity.IMPORTANCEEnteric infections induce dysbiosis and inflammation and are a major public health burden. As the gut environment is strongly shaped by diet, the role of different dietary components in promoting resistance to infection is of interest. While diets rich in fiber or whole grain are normally associated with improved gut health, we show here that these components predispose the host to higher levels of pathogen infection. Thus, our results have significance for interpreting how different dietary interventions may impact on gastrointestinal infections. Moreover, our results may shed light on our understanding of how gut flora and mucosal immune function is influenced by the food that we eat.