Exchange of cellular components between platelets and tumor cells: impact on tumor cells behavior
Alba Rodríguez‐Martínez, Iris Simón, Sonia Perales, M. Carmen Garrido-Navas, Alessandro Russo, Diego de Miguel‐Pérez, Ignacio Puche‐Sanz, Clara Alaminos, Jorge Ceron-Hernandez, José A. Lorente, Maria P. Molina, Coral González‐Martínez, Massimo Cristofanilli, Alba Ortigosa‐Palomo, Pedro J. Real, Christian Rolfo, María José Serrano
Abstract
Our results demonstrated, for the first time, that platelets educate tumor cells by highly efficient transference of lipids, proteins and RNA through different mechanisms. These results suggest that tumor cells and CTCs might acquire highly dynamic and aggressive phenotypes due to platelets interaction including EMT, stem-like phenotype and high proliferative rates.
Topics & Concepts
PlateletCirculating tumor cellCarcinogenesisPhenotypeBiologyPlatelet activationTumor progressionCellCancer researchCell biologyCancerImmunologyMetastasisBiochemistryGeneGeneticsInflammatory Biomarkers in Disease PrognosisCancer, Lipids, and MetabolismCancer-related molecular mechanisms research