The PTGS2/COX2-PGE<sub>2</sub> signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus
Eugenia Martín-Vázquez, Nadia Cobo‐Vuilleumier, Livia López–Noriega, Petra I. Lorenzo, Benoit R. Gauthier
Abstract
as both, cause and consequence of inflammation. Herein, we review the main effects of this molecular pathway in a tissue-specific manner, with a special emphasis on beta cell mass protection/destruction and its potential role in the prevention or development of T1DM. We also discuss strategies to target this pathway for future therapies.
Topics & Concepts
InflammationLipid signalingProstaglandin E2CyclooxygenaseSignal transductionProstaglandin EDiabetes mellitusBiologyImmune systemCell biologyCell signalingImmunologyEndocrinologyMedicineEnzymeBiochemistryInflammatory mediators and NSAID effectsDiabetes and associated disordersHelicobacter pylori-related gastroenterology studies