MOF‐Based Single‐Atom and Metal Cluster Catalysts by Room‐Temperature Synthesis for Tumor Therapy
Subin Yu, Haeun Kang, Seohyeon Jee, WooYeon Moon, Dohyub Jang, Wen‐Tse Huang, Dong-Jun Kim, Dong-Jun Kim, Kyungwha Chung, Dong‐Il Won, Jungwon Park, Ru‐Shi Liu, Kyungmin Choi, Sehoon Kim, Luke P. Lee, Dong Ha Kim, Dong Ha Kim
Abstract
Abstract Metal–organic frameworks (MOFs) are widely used as substrates for creating single‐atom catalysts due to their abundance of ligands, facilitating enzyme‐like activity for biomedical applications. However, the high‐temperature calcination process for single‐atom catalysts limits economical, efficient, and large‐scale synthesis. Here, a simple room‐temperature synthesis of MOF‐based single‐atom and metal cluster catalysts is presented for tumor therapy. Fe/MOF is obtained through a coordination reaction at room temperature, while Au/MOF is synthesized from Au 3+ /MOF by introducing a reducing agent. Au/MOF effectively generates hydrogen peroxide (H 2 O 2 ) from glucose, outperforming Au 3+ /MOF, and Fe/MOF subsequently produced hydroxyl radicals (•OH) by decomposing the generated H 2 O 2 via accelerated peroxidase‐like activity in an acidic environment. In vitro and in vivo studies confirm a significantly enhanced cancer eradication ability compared to the PBS‐treated group by combining cascade enzymatic activity, destruction of oxidative homeostasis, and excessive mitochondrial‐mediated lipid peroxidation. The novel synthesis process of MOF‐based metal single‐atom catalysts establishes a new paradigm for fabricating effective enzyme‐like nanomaterials for multimodal tumor therapy.