Dissecting the biosynthesis of the polyketide alkaloid lydicamycin using a complex metabolic network
Heqian Zhang, Xiaojie Li, Shiyu Pan, Jiaquan Huang, Zhiwei Qin
Abstract
Using a combination of molecular networking and genetics, we preliminarily demonstrate the biosynthesis of type I polyketide alkaloid lydicamycins.
Topics & Concepts
ChemistryPolyketideBiosynthesisAlkaloidStereochemistryComputational biologyBiochemistryGeneBiologyMicrobial Natural Products and BiosynthesisMicrobial Metabolic Engineering and BioproductionGenomics and Phylogenetic Studies