3p-C-NETA: A versatile and effective chelator for development of Al<sup>18</sup>F-labeled and therapeutic radiopharmaceuticals
Stephen Ahenkorah, Erika Murce, Christopher Cawthorne, Jessica Pougoue Ketchemen, Christophe M. Deroose, Thomas Cardinaels, Yann Seimbille, Humphrey Fonge, Willy Gsell, Guy Bormans, Maarten Ooms, Frederik Cleeren
Abstract
Background: Radiolabeled somatostatin analogues (e.g. [ 68 Ga]Ga-DOTATATE and [ 177 Lu]Lu-DOTATATE) have been used to diagnose, monitor, and treat neuroendocrine tumour (NET) patients with great success.
Topics & Concepts
Radionuclide therapyChemistrySomatostatin receptorSomatostatinRadiosynthesisNeuroendocrine tumorsIn vitroChelationPharmacokineticsRadiochemistryCombinatorial chemistryNuclear medicinePharmacologyBiochemistryMedicineReceptorPositron emission tomographyInternal medicineOrganic chemistryRadiopharmaceutical Chemistry and ApplicationsPeptidase Inhibition and AnalysisChemical Synthesis and Analysis