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Dual inhibition of Src and PLK1 regulate stemness and induce apoptosis through Notch1-SOX2 signaling in EGFRvIII positive glioma stem cells (GSCs)

Xuetao Li, Zhennan Tao, Hao Wang, Zhitong Deng, Youxin Zhou, Ziwei Du

2020Experimental Cell Research19 citationsDOI

Topics & Concepts

SOX2BiologyCancer researchGliomaProto-oncogene tyrosine-protein kinase SrcStem cellCancer stem cellPLK1Signal transductionTumor progressionCell biologyApoptosisCancerCell cycleTranscription factorGeneticsGeneGlioma Diagnosis and TreatmentMicroRNA in disease regulationCancer-related molecular mechanisms research
Dual inhibition of Src and PLK1 regulate stemness and induce apoptosis through Notch1-SOX2 signaling in EGFRvIII positive glioma stem cells (GSCs) | Litcius