KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis
Mingzi Li, Mingxun Zhang, Muling Chen, Jiantao Xiao, Xingyu Mu, Jingtao Peng, Jie Fan
Abstract
ccRCC: clear cell renal cell carcinoma; ChIP: chromatin immunoprecipitation; circRNA: circular RNA; EDU: 5-ethynyl-2'-deoxyuridine; EMT: epithelial-mesenchymal transition; FBS: fetal bovine serum; FISH: RNA fluorescent in situ hybridization; KLF2: Kruppel-like factor 2; NC: normal control; NK cell: natural killer cell; NOD/SCID: nonobese severe diabetic/severe combined immunodeficiency; PIM1: Pim-1 proto-oncogene, serine/threonine kinase; RCC: renal cell carcinoma; ZKSCAN1: zinc finger with KRAB and SCAN domains 1.
Topics & Concepts
Clear cell renal cell carcinomaCancer researchBiologyPIM1Gene knockdownCell growthKLF2CancerCellRenal cell carcinomaApoptosisPathologyDownregulation and upregulationCell biologyMedicinePhosphorylationBiochemistryGeneGeneticsSerineCircular RNAs in diseasesMicroRNA in disease regulationKruppel-like factors research