Photosynthesis pneumatic patch promoted deep-wound healing
Qing Li, Bowen Li, Run Yang, Xuheng Chen, Chenxu Shang, Guoqing Feng, Zhengyu Wu, Yue Teng, Huagang He, Yang Bai, Bin Zheng
Abstract
Deep-wound healing, especially in wounds extending into the adipose layer, remains a significant clinical challenge due to inadequate treatment depth, persistent inflammation, hypoxia, and a high risk of infection. To address these issues, we developed a photosynthesis-based dual-layer pneumatic microneedle system that integrates oxygen-producing cyanobacteria with sesamin. This system enhances the wound-healing process by delivering oxygen and therapeutic agents directly to deep tissues, improving the wound's biochemical and cellular environment. The cyanobacteria generate oxygen, facilitating sesamin release, which in turn activates adipocytes, increases adiponectin production, and modulates metabolism, inflammation, and blood supply. Through gas propulsion mechanisms, the system achieves drug penetration depths of up to 1,000 μm, effectively targeting subcutaneous tissues. Preclinical evaluations in a diabetic wound model demonstrated accelerated healing, reduced inflammation, and improved tissue regeneration. This microneedle technology not only offers enhanced drug-delivery capabilities but also provides a promising solution for complex wound management.