Rh(<scp>iii</scp>)-Catalyzed regioselective C4 alkylation of indoles with allylic alcohols: direct access to β-indolyl ketones
Changduo Pan, Gao Huang, Yujia Shan, Yiting Li, Jin‐Tao Yu
Abstract
A Rh(iii)-catalyzed and weak coordination carbonyl guided direct C4 alkylation of indoles with allylic alcohols was developed with excellent regioselectivity. This reaction was conducted under mild conditions, leading to a variety of β-indolyl ketones with good functional group tolerance in moderate to good yields.
Topics & Concepts
ChemistryRegioselectivityAlkylationTsuji–Trost reactionAllylic rearrangementCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Alkyne Reactions