A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression
Zhangchuan Xia, Xin Yang, Sviatlana N. Samovich, Yulia Y. Tyurina, Vladimir A. Tyurin, Ning Kon, Jiankang Zhang, Xuejun Jiang, Brent R. Stockwell, Jian Jin, Hülya Bayir, Valerian E. Kagan, Wei Gu
Topics & Concepts
GPX4Cell biologyGene knockdownIn vivoBiologyPhosphatidic acidReactive oxygen speciesGPX1Lipid peroxidationEndoplasmic reticulumCancer cellProgrammed cell deathRegulatorCancer researchGlutathione peroxidasePhospholipid-hydroperoxide glutathione peroxidaseExtracellularCellApoptosisChemistryGlutathioneBiochemistryDiacylglycerol kinaseOxidative stressPeroxidaseFerroptosis and cancer prognosisRedox biology and oxidative stressCancer, Lipids, and Metabolism