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Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression

Ola Karmi, Yang‐Sung Sohn, Sara I. Zandalinas, Linda Rowland, Skylar D. King, Rachel Nechushtai, Ron Mittler

2021Free Radical Biology and Medicine43 citationsDOIOpen Access PDF

Topics & Concepts

TXNIPThioredoxin-Interacting ProteinCell biologyMitochondrionBiologyCancer cellReactive oxygen speciesCytosolThioredoxinCancer researchChemistryCancerOxidative stressBiochemistryGeneticsEnzymeFerroptosis and cancer prognosisEpigenetics and DNA MethylationRNA modifications and cancer
Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression | Litcius