Gold-coated iron oxide nanoparticles as a potential photothermal therapy agent to enhance eradication of breast cancer cells
Mohammed Ali Dheyab, Azlan Abdul Aziz, Mahmood S. Jameel, Pegah Moradi Khaniabadi, Baharak Mehrdel, Bita Moradi Khaniabadi
Abstract
Abstract Iron oxide nanoparticles (Fe 3 O 4 NPs) possess unique physicochemical properties which make them great for biomedical applications. This study reports the development of gold (Au) coated Fe3O4 (Au-Fe3O4 NPs) for photothermal therapy to eradicate breast cancer cells (MCF-7). The spherical shape of monodisperse Au-Fe 3 O 4 NPs with an average size of 20.8 nm was confirmed by TEM. The cell viability evaluation of Au-Fe 3 O 4 NPs showed negligible toxicity toward MCF-7 cells after 24 h. Significant cell reduction was observed for MCF-7 (73.9%) cells following photothermal therapy at highest concentration of NPs (50 μgFe/ml) for 10 minutes illumination when compared with other intervention groups. It can be concluded that, the synthesized Au-Fe 3 O 4 NPs is an effective and promising photothermal therapy agent for breast cancer treatment.