CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models
Haineng Xu, Erin George, Yasuto Kinose, Hyoung Kim, Jennifer Shah, Jasmine D. Peake, Benjamin Ferman, Sergey Medvedev, Thomas Murtha, Carter J. Barger, Kyle M. Devins, Kurt D’Andrea, Bradley Wubbenhorst, Lauren E. Schwartz, Wei‐Ting Hwang, Gordon B. Mills, Katherine L. Nathanson, Adam R. Karpf, Ronny Drapkin, Eric J. Brown, Fiona Simpkins
Abstract
CN is a clinically tractable biomarker predicting responsiveness to low-dose WEE1i-ATRi for aggressive subsets of OVCAs/EMCAs.
Topics & Concepts
BiomarkerCancer researchOvarian cancerWee1DNA damageOlaparibBiologyOncologyCell cycleCancerMedicineInternal medicineDNAGeneticsPoly ADP ribose polymerasePolymeraseCyclin-dependent kinase 1DNA Repair MechanismsRenal and related cancersPARP inhibition in cancer therapy