circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion
Minyue Tang, Long Bai, Zhe Wan, Shan Wan, Yu Xiang, Yeqing Qian, Long Cui, Jiali You, Xiaoling Hu, Fan Qu, Yimin Zhu
Abstract
, the numbers of implanted embryos decreased significantly. These results reveal the regulatory roles of circRNA-DURSA in trophoblasts and identified a distinct circRNA-DURSA/miR-760/HIST1H2BE axis as potentially important diagnostic and therapeutic targets for URSA treatment.
Topics & Concepts
AbortionTrophoblastApoptosisMedicineCancer researchBiologyPregnancyGeneticsFetusPlacentaCircular RNAs in diseasesPregnancy and preeclampsia studiesReproductive System and Pregnancy