Simultaneous quantification of dabrafenib, hydroxy-dabrafenib and trametinib in human plasma by liquid chromatography-tandem mass spectrometry
David Balakirouchenane, Nihel Khoudour, Sarah Guégan, N. Kramkimel, Nathalie Franck, Thomas Rodier, François Goldwasser, N. Dupin, S. Aractingi, Michel Vidal, Benoı̂t Blanchet
Topics & Concepts
DabrafenibFormic acidChromatographyChemistryProtein precipitationTrametinibLiquid chromatography–mass spectrometryMass spectrometryTandem mass spectrometryCancerBiochemistryKinaseMedicineMAPK/ERK pathwayVemurafenibMetastatic melanomaInternal medicineMelanoma and MAPK PathwaysQuinazolinone synthesis and applicationsChronic Myeloid Leukemia Treatments