Astragaloside IV attenuate MI-induced myocardial fibrosis and cardiac remodeling by inhibiting ROS/caspase-1/GSDMD signaling pathway
Xiaoqing Zhang, Huiyan Qu, Tao Yang, Qian Liu, Hua Zhou
Abstract
, AS-IV was selected to stimulate bone marrow-derived macrophages (BMDMs). Our findings indicated that AS-IV protective effect of the heart might be related to the reduction of macrophage pyroptosis. These results demonstrate that AS-IV alleviated MI-induced myocardial fibrosis and cardiac remodeling by suppressing ROS/Caspase-1/GSDMD signaling pathway, AS-IV should be further studied in the future.
Topics & Concepts
BiologyCell biologySignal transductionCardiac fibrosisFibrosisMyocardial fibrosisApoptosisVentricular remodelingCaspaseCancer researchPharmacologyMyocardial infarctionInternal medicineProgrammed cell deathBiochemistryMedicineCardiac Fibrosis and RemodelingTraditional Chinese Medicine AnalysisVanadium and Halogenation Chemistry