Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
Elza Evren, Emma Ringqvist, Kumar Parijat Tripathi, Natalie Sleiers, Inés Có Rives, A Alisjahbana, Yu Gao, Dhifaf Sarhan, Tor Halle, Chiara Sorini, Rico Lepzien, Nicole Marquardt, Jakob Michaëlsson, Anna Smed‐Sörensen, Johan Botling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Tim Willinger
Abstract
blood monocytes preferentially generated macrophages resident in the lung vasculature (pulmonary intravascular macrophages). Finally, single-cell RNA sequencing defined intermediate differentiation stages in human lung macrophage development from blood monocytes. This study identifies distinct developmental pathways from circulating monocytes to lung macrophages and reveals how cellular origin contributes to human macrophage identity, diversity, and localization in vivo.