Abiotic Transformation of Lamotrigine by Redox-Active Mineral and Phenolic Compounds
Marina Karpov, Bettina Seiwert, Vered Mordehay, Thorsten Reemtsma, Tamara Polubesova, Benny Chefetz
Abstract
-methoxyphenol induced 48% transformation (35 TPs were identified). In the bisolute system with phenolic compounds, lamotrigine has possibly been transformed mainly via addition reactions with phenolic compounds and their oxidation products (protocatechuic acid, quinone, and oligomers). Thus, masses of the formed TPs were elevated as compared to the parent compound. The current study demonstrates the important role of redox-active minerals and naturally occurring phenolic compounds in abiotic removal and transformation of a recalcitrant environmental pollutant.
Topics & Concepts
ChemistryVanillic acidLamotrigineRedoxOrganic chemistryEnvironmental chemistryBiologyEpilepsyNeurosciencePharmaceutical and Antibiotic Environmental ImpactsPharmacological Effects and Toxicity Studies