Coupling of amides with ketones <i>via</i> C–N/C–H bond cleavage: a mild synthesis of 1,3-diketones
Jiajia Chen, Yuanzhi Xia, Sunwoo Lee
Abstract
Amides react with enolizable ketones to give 1,3-diketones <italic>via</italic> C–N cleavage of amides and deprotonation of ketones.
Topics & Concepts
ChemistryDeprotonationCleavage (geology)Bond cleavageKetoneMedicinal chemistryStereochemistryCoupling (piping)Organic chemistryCatalysisIonMechanical engineeringEngineeringFracture (geology)Geotechnical engineeringAdvanced Synthetic Organic ChemistryCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis