Enantioselective Heck‐Matsuda Reactions: From Curiosity to a Game‐Changing Methodology
Caio C. Oliveira, Carlos Roque D. Correia
Abstract
The enantioselective palladium-catalyzed Heck arylation of olefins using arenediazonium salts is one of the last features in the evolution of a synthetic method known as the Heck-Matsuda reaction. This personal account highlights the development of the enantioselective Heck-Matsuda reaction in its initial stages, the challenges faced along the way, and the interesting findings that opened new synthetic opportunities, mainly from our laboratory, featuring the Heck-Matsuda reaction as a central player in the synthesis of bioactive and functional molecules.
Topics & Concepts
Enantioselective synthesisHeck reactionCuriosityPalladiumChemistryOrganic chemistryCombinatorial chemistryCatalysisPsychologySocial psychologyCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsChemical synthesis and alkaloids