Design and synthesis of diosgenin derivatives as apoptosis inducers through mitochondria-related pathways
Liwei Ma, Jinling Zhang, Xuemei Wang, Jifang Yang, Lina Guo, Xiaoli Wang, Bo Song, Wei Dong, Wenbao Wang
Topics & Concepts
ChemistryApoptosisCytotoxic T cellCytotoxicityGambogic acidDownregulation and upregulationDiosgeninCell cultureReactive oxygen speciesK562 cellsMitochondrionBiochemistryPharmacologyIn vitroBiologyGeneOrganic chemistryGeneticsPhytochemical Studies and BioactivitiesMarine Sponges and Natural ProductsBioactive Natural Diterpenoids Research