Mechanisms underlying the prokinetic effects of endogenous glucagon-like peptide-1 in the rat proximal colon
Hiroyuki Nakamori, Koji Iida, Hikaru Hashitani
Abstract
Glucagon-like peptide-1 (GLP-1) activates CGRP-containing intrinsic afferent neurons resulting in the acceleration of colonic peristalsis. Short-chain fatty acids stimulate the secretion of endogenous GLP-1 from L cells that accelerates colonic peristalsis. Thus, besides the well-known humoral insulinotropic action, GLP-1 exerts a local action via the activation of the enteric nervous system to accelerate colonic motility. Such a prokinetic action of GLP-1 could underlie the mechanisms causing diarrhea in patients with type-2 diabetes treated with GLP-1 analogs.
Topics & Concepts
PeristalsisGlucagon-like peptide-2Glucagon-like peptide-1Internal medicineEndogenyMotilityEnteroendocrine cellEndocrinologyGastrointestinal hormoneSecretionEnteric nervous systemChemistryPeptide hormonePeptideMedicineBiologyReceptorHormoneType 2 diabetesDiabetes mellitusEndocrine systemBiochemistryCell biologyDiabetes Treatment and ManagementGastrointestinal motility and disordersHelicobacter pylori-related gastroenterology studies