Multifunction in One Nanoparticle for Anticancer Therapy: Bowl-Shaped Au@PDA Yolk–Shell NPs
Xin Ding, Tianyu Wang, Shiwei Bai, Yunfeng Wan, Shuai Zhu, Tao Li, Na Peng, Tao Qiu, Yi Liu
Abstract
Multifunctional nanoparticles (NPs) with simultaneous multimodal therapeutic and imaging capabilities are very necessary for biomedical applications. We successfully prepared bowl-shaped gold@polydopamine yolk–shell NPs (bowl-shaped Au@PDA YNPs) by a novel and facile method. The unique bowl-like structure enables a drug loading rate of 92% (920 μg mg–1). The bowl-shaped Au@PDA YNPs are biocompatible, have good photothermal conversion and strong near-infrared (NIR) absorption, and can control drug release under pH/NIR dual response. Bowl-shaped Au@PDA YNPs can also be employed as contrast agents for computed tomography/photoacoustic imaging for dual-modal imaging-guided chemotherapy and photothermal therapy due to the presence of Au NPs.