Synthesis and biological evaluation of a tumor-selective degrader of PARP1
Chunlan Pu, Shirui Wang, Dan Luo, Yuanyuan Liu, Xinyu Ma, Hongjia Zhang, Su Yu, Suke Lan, Qing Huang, Rui Deng, Xianghuo He, Rui Li
Topics & Concepts
OlaparibChemistryPARP1Poly ADP ribose polymeraseLinkerCereblonProteolysisCancer researchCancer cellUbiquitin ligasePolymeraseSmall moleculeBiochemistryCancerUbiquitinPharmacologyDNAEnzymeBiologyGeneComputer scienceOperating systemGeneticsPARP inhibition in cancer therapyProtein Degradation and InhibitorsAdvancements in Semiconductor Devices and Circuit Design