Tailorable and Biocompatible Supramolecular‐Based Hydrogels Featuring two Dynamic Covalent Chemistries
Ivana Marić, Liangliang Yang, Xiufeng Li, Guillermo Monreal Santiago, Charalampos G. Pappas, Xinkai Qiu, Joshua A. Dijksman, Kirill I. Mikhailov, Patrick van Rijn, Sijbren Otto
Abstract
Abstract Dynamic covalent chemistry (DCC) has proven to be a valuable tool in creating fascinating molecules, structures, and emergent properties in fully synthetic systems. Here we report a system that uses two dynamic covalent bonds in tandem, namely disulfides and hydrazones, for the formation of hydrogels containing biologically relevant ligands. The reversibility of disulfide bonds allows fiber formation upon oxidation of dithiol‐peptide building block, while the reaction between NH−NH 2 functionalized C‐terminus and aldehyde cross‐linkers results in a gel. The same bond‐forming reaction was exploited for the “decoration” of the supramolecular assemblies by cell‐adhesion‐promoting sequences (RGD and LDV). Fast triggered gelation, cytocompatibility and ability to “on‐demand” chemically customize fibrillar scaffold offer potential for applying these systems as a bioactive platform for cell culture and tissue engineering.