Catalytic [4 + 1]-annulation of thioamides with carbenoid precursors
Vladimir G. Ilkin, Valeriy O. Filimonov, Irina A. Utepova, Tetyana Beryozkina, Павел А. Слепухин, А. А. Тумашов, Wim Dehaen, Vasiliy А. Bakulev
Abstract
Catalyst-controlled regioselective and diastereoselective reactions of thioamides with diazoamides and 1-sulfonyl-1,2,3-triazoles was developed. Enantioselective and gram-scale syntheses were performed.
Topics & Concepts
ChemistryCarbenoidAnnulationCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryRhodiumCyclopropane Reaction MechanismsSynthesis and Catalytic ReactionsSynthesis and Reactivity of Heterocycles