IFN-γ <sup>–/–</sup> Mice Resist Actinobacillus pleuropneumoniae Infection by Promoting Early Lung IL-18 Release and PMN-I Accumulation
Chuntong Bao, Baijun Liu, Rining Zhu, Jiameng Xiao, Ziheng Li, Hexiang Jiang, Beinan Wang, Paul R. Langford, Rui Fei, Na Li, Liancheng Lei
Abstract
-infected mice. This study identifies IFN-γ as a target for regulating the inflammatory response in the lung and provides a basis for understanding the course of clinical bacterial pneumonia and for the formulation of treatment protocols.
Topics & Concepts
Actinobacillus pleuropneumoniaePleuropneumoniaBiologyMicrobiologyLungVirologyInterferon gammaImmunologyActinobacillusImmune systemBacteriaMedicineSerotypeInternal medicineGeneticsMicrobial infections and disease researchAnimal Virus Infections StudiesAquaculture disease management and microbiota