Pharmacologically targeting fatty acid synthase-mediated de novo lipogenesis alleviates osteolytic bone loss by directly inhibiting osteoclastogenesis through suppression of STAT3 palmitoylation and ROS signaling
Chunmei Xiu, Lei Zhang, Chenxi Zhang, Yanxia Zhang, Xi Luo, Ziyi Zhang, Hangkai Zhao, Kaizhong Ji, Zhiyuan Chen, Guangxu He, Jianquan Chen
Topics & Concepts
PalmitoylationLipogenesisFatty acid synthaseChemistryCell biologyLipid signalingFatty acid synthesisCancer researchFatty acidBiologyLipid metabolismBiochemistryReceptorEnzymeCysteineBone health and treatmentsBone Metabolism and DiseasesCancer, Lipids, and Metabolism